abstract：BACKGROUND:Deferring percutaneous coronary intervention in nonischemic lesions by fractional flow reserve (FFR) is associated with excellent long-term prognosis in patients with stable ischemic heart disease (SIHD). Although FFR is increasingly used for clinical decision making in acute coronary syndrome (ACS) patients...

journal_title：Journal of the American College of Cardiology

authors： Hakeem A,Edupuganti MM,Almomani A,Pothineni NV,Payne J,Abualsuod AM,Bhatti S,Ahmed Z,Uretsky BF

更新日期：2016-09-13 00:00:00

abstract：:Left ventricular noncompaction (LVNC) describes a ventricular wall anatomy characterized by prominent left ventricular (LV) trabeculae, a thin compacted layer, and deep intertrabecular recesses. Individual variability is extreme, and trabeculae represent a sort of individual "cardioprinting." By itself, the diagnosis ...

journal_title：Journal of the American College of Cardiology

authors： Arbustini E,Favalli V,Narula N,Serio A,Grasso M

更新日期：2016-08-30 00:00:00

abstract：BACKGROUND:The 2013 American College of Cardiology (ACC)/American Heart Association (AHA) guidelines recommend primary prevention with statins for individuals with ≥7.5% 10-year risk for atherosclerotic cardiovascular disease (ASCVD). Everyone living long enough will become eligible for risk-based statin therapy due to...

journal_title：Journal of the American College of Cardiology

authors： Mortensen MB,Fuster V,Muntendam P,Mehran R,Baber U,Sartori S,Falk E

更新日期：2016-08-30 00:00:00

abstract：BACKGROUND:Although guideline-recommended therapies reduce major adverse cardiovascular events (MACE) in patients after myocardial infarction (MI) or those with atherosclerotic disease (ATH), adherence is poor. OBJECTIVES:The goal of this study was to determine the association between medication adherence levels and l...

journal_title：Journal of the American College of Cardiology

authors： Bansilal S,Castellano JM,Garrido E,Wei HG,Freeman A,Spettell C,Garcia-Alonso F,Lizano I,Arnold RJ,Rajda J,Steinberg G,Fuster V

更新日期：2016-08-23 00:00:00

abstract：:The development of aortic valve-sparing operations (reimplantation of the aortic valve and remodeling of the aortic root) expanded the surgical armamentarium for treating patients with aortic root dilation caused by a variety of disorders. Young adults with aortic root aneurysms associated with genetic syndromes are i...

journal_title：Journal of the American College of Cardiology

authors： David TE

更新日期：2016-08-09 00:00:00

abstract：BACKGROUND:Residual aortic regurgitation (AR) following transcatheter aortic valve replacement (TAVR) is associated with greater mortality; yet, determining AR severity post-TAVR using Doppler echocardiography remains challenging. Cardiovascular magnetic resonance (CMR) is purported as a more accurate means of quantify...

journal_title：Journal of the American College of Cardiology

authors： Ribeiro HB,Orwat S,Hayek SS,Larose É,Babaliaros V,Dahou A,Le Ven F,Pasian S,Puri R,Abdul-Jawad Altisent O,Campelo-Parada F,Clavel MA,Pibarot P,Lerakis S,Baumgartner H,Rodés-Cabau J

更新日期：2016-08-09 00:00:00

abstract：:Non-ST-segment elevation acute coronary syndromes (NSTE-ACS) are the leading cause of morbidity and mortality from cardiovascular disease worldwide. The American Heart Association/American College of Cardiology and the European Society of Cardiology periodically release practice guidelines to guide clinicians in the m...

journal_title：Journal of the American College of Cardiology

authors： Rodriguez F,Mahaffey KW

更新日期：2016-07-19 00:00:00

abstract：BACKGROUND:Patients with heart failure (HF) are at high risk for hospital readmission in the first 30 days following HF hospitalization. OBJECTIVES:This study sought to determine if treatment with sacubitril/valsartan (LCZ696) reduces rates of hospital readmission at 30-days following HF hospitalization compared with ...

journal_title：Journal of the American College of Cardiology

authors： Desai AS,Claggett BL,Packer M,Zile MR,Rouleau JL,Swedberg K,Shi V,Lefkowitz M,Starling R,Teerlink J,McMurray JJV,Solomon SD,PARADIGM-HF Investigators.

更新日期：2016-07-19 00:00:00

abstract：:Cardiovascular evaluation and care of college student-athletes is gaining increasing attention from both the public and medical communities. Emerging strategies include screening of the general athlete population, recommendations of permissible levels of participation by athletes with identified cardiovascular conditi...

journal_title：Journal of the American College of Cardiology

authors： Hainline B,Drezner JA,Baggish A,Harmon KG,Emery MS,Myerburg RJ,Sanchez E,Molossi S,Parsons JT,Thompson PD

更新日期：2016-06-28 00:00:00

abstract：BACKGROUND:Blood pressure (BP) targets from the SPRINT (Systolic Blood Pressure Intervention Trial) differ from targets of the 2014 hypertension (HTN) recommendations of the Eighth Joint National Committee. OBJECTIVES:The goal of this study was to estimate the proportion of hypertensive adults with who would meet BP g...

journal_title：Journal of the American College of Cardiology

authors： Ko MJ,Jo AJ,Park CM,Kim HJ,Kim YJ,Park DW

更新日期：2016-06-21 00:00:00

abstract：BACKGROUND:Patients with diabetes appear to be at elevated risk of atherothrombotic events. OBJECTIVES:The purpose of this study was to determine the effect of antiplatelet therapy with ticagrelor on recurrent ischemic events in patients with diabetes and prior myocardial infarction (MI). METHODS:We examined the subg...

journal_title：Journal of the American College of Cardiology

authors： Bhatt DL,Bonaca MP,Bansilal S,Angiolillo DJ,Cohen M,Storey RF,Im K,Murphy SA,Held P,Braunwald E,Sabatine MS,Steg PG

更新日期：2016-06-14 00:00:00

abstract：BACKGROUND:Pheochromocytoma is associated with catecholamine-induced cardiac toxicity, but the extent and nature of cardiac involvement in clinical cohorts is not well-characterized. OBJECTIVES:This study characterized the cardiac phenotype in patients with pheochromocytoma using cardiac magnetic resonance (CMR). MET...

journal_title：Journal of the American College of Cardiology

authors： Ferreira VM,Marcelino M,Piechnik SK,Marini C,Karamitsos TD,Ntusi NAB,Francis JM,Robson MD,Arnold JR,Mihai R,Thomas JDJ,Herincs M,Hassan-Smith ZK,Greiser A,Arlt W,Korbonits M,Karavitaki N,Grossman AB,Wass JAH,Neubaue

更新日期：2016-05-24 00:00:00

abstract：BACKGROUND:It is widely believed that a reduced cardiac index (CI) is a significant contributor to renal dysfunction in patients with heart failure (HF). However, recent data have challenged this paradigm. OBJECTIVES:This study sought to determine the relationship between CI and renal function in a multicenter populat...

journal_title：Journal of the American College of Cardiology

authors： Hanberg JS,Sury K,Wilson FP,Brisco MA,Ahmad T,Ter Maaten JM,Broughton JS,Assefa M,Tang WHW,Parikh CR,Testani JM

更新日期：2016-05-17 00:00:00

abstract：:The American College of Cardiology Emerging Faculty program was developed in 2005 to promote a systematic approach to "educate the educators" through training and mentorship. A primary focus of the program is the biennial Teaching Skills Workshop, which has had 130 participants since its inception and is focused on th...

journal_title：Journal of the American College of Cardiology

authors： Auseon AJ,O'Gara PT,Klodas E,Holmes DR Jr,Jackson MJ,Green JS,Konstam MA,Nishimura RA

更新日期：2016-05-10 00:00:00

abstract：BACKGROUND:Critical limb ischemia (CLI) continues to be a major cause of vascular-related morbidity and mortality in the United States. OBJECTIVES:The study sought to characterize the trends in hospitalization of U.S. patients with CLI from 2003 to 2011, using the Nationwide Inpatient Sample. We compared the cost util...

journal_title：Journal of the American College of Cardiology

authors： Agarwal S,Sud K,Shishehbor MH

更新日期：2016-04-26 00:00:00

abstract：:Venous thromboembolism (VTE) is a common disease associated with high risk for recurrences, death, and late sequelae, accounting for substantial health care costs. Anticoagulant agents are the mainstay of treatment for deep vein thrombosis and pulmonary embolism. The recent availability of oral anticoagulant agents th...

journal_title：Journal of the American College of Cardiology

authors： Becattini C,Agnelli G

更新日期：2016-04-26 00:00:00

abstract：BACKGROUND:Data suggest that T1 and T2 mapping have excellent diagnostic accuracy in patients with suspected myocarditis. However, the true diagnostic performance of comprehensive cardiac magnetic resonance (CMR) mapping versus endomyocardial biopsy (EMB) has not been determined. OBJECTIVES:This study assessed the per...

journal_title：Journal of the American College of Cardiology

authors： Lurz P,Luecke C,Eitel I,Föhrenbach F,Frank C,Grothoff M,de Waha S,Rommel KP,Lurz JA,Klingel K,Kandolf R,Schuler G,Thiele H,Gutberlet M

更新日期：2016-04-19 00:00:00

abstract：:Cardiovascular disease is the leading cause of mortality in the world, and the increasing burden is largely a consequence of modifiable behavioral risk factors that interact with genomics and the environment. Continuous cardiovascular health promotion and disease prevention throughout the lifespan is critical, and the...

journal_title：Journal of the American College of Cardiology

authors： Vedanthan R,Bansilal S,Soto AV,Kovacic JC,Latina J,Jaslow R,Santana M,Gorga E,Kasarskis A,Hajjar R,Schadt EE,Björkegren JL,Fayad ZA,Fuster V

更新日期：2016-04-12 00:00:00

abstract：:Drug-induced long QT syndrome (diLQTS) and congenital LQTS (cLQTS) share many features, and both syndromes can result in life-threatening torsades de pointes (TdP). Our understanding of their mechanistic and genetic similarities has led to their improved clinical management. However, our inability to prevent diLQTS ha...

journal_title：Journal of the American College of Cardiology

authors： Schwartz PJ,Woosley RL

更新日期：2016-04-05 00:00:00

abstract：BACKGROUND:Poor adherence to medication regimens is common, potentially contributing to the occurrence of related disease. OBJECTIVES:The authors sought to assess the risk of fatal stroke associated with nonadherence to statin and/or antihypertensive therapy. METHODS:We conducted a population-based study using electr...

journal_title：Journal of the American College of Cardiology

authors： Herttua K,Martikainen P,Batty GD,Kivimäki M

更新日期：2016-04-05 00:00:00

abstract：OBJECTIVE:To review the literature systematically to determine whether noninvasive or invasive risk stratification, such as with an electrophysiological study of patients with asymptomatic pre-excitation, reduces the risk of arrhythmic events and improves patient outcomes. METHODS:PubMed, EMBASE, and the Cochrane Cent...

journal_title：Journal of the American College of Cardiology

authors： Al-Khatib SM,Arshad A,Balk EM,Das SR,Hsu JC,Joglar JA,Page RL

更新日期：2016-04-05 00:00:00

abstract：:Incretin-based therapies are effective glucose-lowering drugs that have an increasing role in the treatment of type 2 diabetes because of their efficacy, safety, and ease of use. Both glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors are commonly used for glycemic control as adjuncts to m...

journal_title：Journal of the American College of Cardiology

authors： Waldrop G,Zhong J,Peters M,Rajagopalan S

更新日期：2016-03-29 00:00:00

abstract：BACKGROUND:Persistent severe left ventricular (LV) systolic dysfunction after myocardial infarction (MI) is associated with increased mortality and is a class I indication for implantation of a cardioverter-defibrillator. OBJECTIVES:This study developed models and assessed independent predictors of LV recovery to >35%...

journal_title：Journal of the American College of Cardiology

authors： Brooks GC,Lee BK,Rao R,Lin F,Morin DP,Zweibel SL,Buxton AE,Pletcher MJ,Vittinghoff E,Olgin JE,PREDICTS Investigators.

更新日期：2016-03-15 00:00:00

abstract：:Compared with recent advances in treatment of serious cardiovascular diseases, such as myocardial infarction and stroke, the treatment and outcome of acute pulmonary embolism (PE) have remained relatively unchanged over the last few decades. This has prompted several experts to call for the formation of multidisciplin...

journal_title：Journal of the American College of Cardiology

authors： Jaber WA,Fong PP,Weisz G,Lattouf O,Jenkins J,Rosenfield K,Rab T,Ramee S

更新日期：2016-03-01 00:00:00

abstract：:SCOT-HEART (Scottish COmputed Tomography of the HEART) and PROMISE (PROspective Multicenter Imaging Study for Evaluation of chest pain) represent the 2 largest and most comprehensive cardiovascular imaging outcome trials in patients with stable chest pain and provide significant insights into patient diagnosis, manage...

journal_title：Journal of the American College of Cardiology

authors： Fordyce CB,Newby DE,Douglas PS

更新日期：2016-02-23 00:00:00

abstract：BACKGROUND:Cardiomyopathies are usually inherited and predominantly affect adults, but they can also present in childhood. Although our understanding of the molecular basis of pediatric cardiomyopathy has improved, the underlying mechanism remains elusive in a substantial proportion of cases. OBJECTIVES:This study aim...

journal_title：Journal of the American College of Cardiology

authors： Almomani R,Verhagen JM,Herkert JC,Brosens E,van Spaendonck-Zwarts KY,Asimaki A,van der Zwaag PA,Frohn-Mulder IM,Bertoli-Avella AM,Boven LG,van Slegtenhorst MA,van der Smagt JJ,van IJcken WF,Timmer B,van Stuijvenberg M,Verdi

更新日期：2016-02-09 00:00:00

abstract：BACKGROUND:A lack of clarity exists about the role of complete coronary revascularization in patients presenting with non-ST-segment elevation myocardial infarction. OBJECTIVES:The aim of our study was to compare long-term outcomes in terms of major adverse cardiovascular and cerebrovascular events of 2 different comp...

journal_title：Journal of the American College of Cardiology

authors： Sardella G,Lucisano L,Garbo R,Pennacchi M,Cavallo E,Stio RE,Calcagno S,Ugo F,Boccuzzi G,Fedele F,Mancone M

更新日期：2016-01-26 00:00:00

abstract：:All patients with stable ischemic heart disease (SIHD) should be managed with guideline-directed medical therapy (GDMT), which reduces progression of atherosclerosis and prevents coronary thrombosis. Revascularization is also indicated in patients with SIHD and progressive or refractory symptoms, despite medical manag...

journal_title：Journal of the American College of Cardiology

authors： Stone GW,Hochman JS,Williams DO,Boden WE,Ferguson TB Jr,Harrington RA,Maron DJ

更新日期：2016-01-05 00:00:00

abstract：BACKGROUND:Familial hypercholesterolemia is typically caused by LDL receptor (LDLR) mutations that result in elevated levels of LDL cholesterol (LDL-C). In homozygous FH, the prevalence of aortic valve calcification (AoVC) reaches 100% and is often symptomatic. OBJECTIVES:The objective of this study was to investigate...

journal_title：Journal of the American College of Cardiology

authors： Ten Kate GR,Bos S,Dedic A,Neefjes LA,Kurata A,Langendonk JG,Liem A,Moelker A,Krestin GP,de Feyter PJ,Roeters van Lennep JE,Nieman K,Sijbrands EJ

更新日期：2015-12-22 00:00:00

abstract：BACKGROUND:The wearable cardioverter-defibrillator (WCD) has emerged as a means of protecting patients with newly diagnosed nonischemic cardiomyopathy (NICM) or ischemic cardiomyopathy (ICM) against sudden cardiac death while awaiting re-evaluation of cardiac function. OBJECTIVES:This study sought to characterize the ...

journal_title：Journal of the American College of Cardiology

authors： Singh M,Wang NC,Jain S,Voigt AH,Saba S,Adelstein EC

更新日期：2015-12-15 00:00:00

abstract：:Cardiovascular disease deaths are increasing in low- and middle-income countries and are exacerbated by health care systems that are ill-equipped to manage chronic diseases. Global health partnerships, which have stemmed the tide of infectious diseases in low- and middle-income countries, can be similarly applied to a...

journal_title：Journal of the American College of Cardiology

authors： Binanay CA,Akwanalo CO,Aruasa W,Barasa FA,Corey GR,Crowe S,Esamai F,Einterz R,Foster MC,Gardner A,Kibosia J,Kimaiyo S,Koech M,Korir B,Lawrence JE,Lukas S,Manji I,Maritim P,Ogaro F,Park P,Pastakia SD,Sugut W,Ve

更新日期：2015-12-08 00:00:00

abstract：BACKGROUND:Isolated tricuspid valve surgery is associated with high morbidity and mortality, especially in patients with prior cardiac surgery. The transcatheter Forma Repair System (Edwards Lifesciences, Irvine, California) is designed to provide a surface for native leaflet coaptation to reduce tricuspid regurgitatio...

journal_title：Journal of the American College of Cardiology

authors： Campelo-Parada F,Perlman G,Philippon F,Ye J,Thompson C,Bédard E,Abdul-Jawad Altisent O,Del Trigo M,Leipsic J,Blanke P,Dvir D,Puri R,Webb JG,Rodés-Cabau J

更新日期：2015-12-08 00:00:00

abstract：BACKGROUND:MicroRNA (miR) dysregulation in the myocardium has been implicated in cardiac remodeling after injury or stress. OBJECTIVES:The aim of this study was to explore the role of miR in human CD34(+) cell (hCD34(+)) dysfunction in vivo after transplantation into the myocardium under ischemia-reperfusion (I-R) con...

journal_title：Journal of the American College of Cardiology

authors： Joladarashi D,Garikipati VNS,Thandavarayan RA,Verma SK,Mackie AR,Khan M,Gumpert AM,Bhimaraj A,Youker KA,Uribe C,Suresh Babu S,Jeyabal P,Kishore R,Krishnamurthy P

更新日期：2015-11-17 00:00:00

abstract：BACKGROUND:The right ventricular outflow tract (RVOT) is acknowledged to be responsible for arrhythmogenesis in Brugada syndrome (BrS), but the pathophysiology remains controversial. OBJECTIVES:This study assessed the substrate underlying BrS at post-mortem and in vivo, and the role for open thoracotomy ablation. MET...

journal_title：Journal of the American College of Cardiology

authors： Nademanee K,Raju H,de Noronha SV,Papadakis M,Robinson L,Rothery S,Makita N,Kowase S,Boonmee N,Vitayakritsirikul V,Ratanarapee S,Sharma S,van der Wal AC,Christiansen M,Tan HL,Wilde AA,Nogami A,Sheppard MN,Veerakul G,

更新日期：2015-11-03 00:00:00

abstract：BACKGROUND:Recent studies from Asia have suggested that the risk of ischemic stroke for patients with atrial fibrillation (AF) with a "low-risk" congestive heart failure, hypertension, age ≥75, diabetes mellitus, prior stroke or transient ischemic attack, vascular disease, age 65 to 74, female (CHA2DS2-VASc) score of 0...

journal_title：Journal of the American College of Cardiology

authors： Chao TF,Wang KL,Liu CJ,Lin YJ,Chang SL,Lo LW,Hu YF,Tuan TC,Chung FP,Liao JN,Chen TJ,Chiang CE,Lip GY,Chen SA

更新日期：2015-09-22 00:00:00

abstract：:Little is known about the benefits and risks of the long-term use of cardiovascular drugs. Evidence from randomized clinical trials (RCTs) rarely goes beyond a few years of follow-up, but patients are often given continuous treatment with multiple drugs well into old age. We focus on 4 commonly used cardiovascular dru...

journal_title：Journal of the American College of Cardiology

authors： Rossello X,Pocock SJ,Julian DG

更新日期：2015-09-15 00:00:00

abstract：BACKGROUND:Randomized trials of percutaneous coronary intervention (PCI) versus coronary artery bypass graft (CABG) routinely exclude patients with chronic kidney disease (CKD). OBJECTIVES:This study evaluated outcomes of PCI versus CABG in patients with CKD. METHODS:Patients with CKD who underwent PCI using everolim...

journal_title：Journal of the American College of Cardiology

authors： Bangalore S,Guo Y,Samadashvili Z,Blecker S,Xu J,Hannan EL

更新日期：2015-09-15 00:00:00

abstract：BACKGROUND:Pericardial effusion (PE) is common in cancer patients, but the optimal therapeutic approach is not well defined. Percutaneous pericardiocentesis is less invasive than surgery, but its long-term effectiveness and safety have not been well documented. OBJECTIVES:The goal of this study was to evaluate outcome...

journal_title：Journal of the American College of Cardiology

authors： El Haddad D,Iliescu C,Yusuf SW,William WN Jr,Khair TH,Song J,Mouhayar EN

更新日期：2015-09-08 00:00:00

abstract：BACKGROUND:In patients with resistant hypertension (RH) and obstructive sleep apnea (OSA), the blood pressure response to continuous positive airway pressure (CPAP) treatment is highly variable and could be associated with differential micro-ribonucleic acid (miRNA) profiles. Currently, no available methods exist to id...

journal_title：Journal of the American College of Cardiology

authors： Sánchez-de-la-Torre M,Khalyfa A,Sánchez-de-la-Torre A,Martinez-Alonso M,Martinez-García MÁ,Barceló A,Lloberes P,Campos-Rodriguez F,Capote F,Diaz-de-Atauri MJ,Somoza M,González M,Masa JF,Gozal D,Barbé F,Spanish Sleep Network

更新日期：2015-09-01 00:00:00

abstract：BACKGROUND:Peripartum cardiomyopathy (PPCM) remains a major cause of maternal morbidity and mortality. OBJECTIVES:This study sought to prospectively evaluate recovery of the left ventricular ejection fraction (LVEF) and clinical outcomes in the multicenter IPAC (Investigations of Pregnancy Associated Cardiomyopathy) s...

journal_title：Journal of the American College of Cardiology

authors： McNamara DM,Elkayam U,Alharethi R,Damp J,Hsich E,Ewald G,Modi K,Alexis JD,Ramani GV,Semigran MJ,Haythe J,Markham DW,Marek J,Gorcsan J 3rd,Wu WC,Lin Y,Halder I,Pisarcik J,Cooper LT,Fett JD,IPAC Investigators.

更新日期：2015-08-25 00:00:00